caa a22 4500 605537461 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2858-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2858-0 Effect of Diprotin A, an Inhibitor of Dipeptidyl Peptidase IV, on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process [Elektronische Daten] [M. Robinson, E. Mel'nikova, V. Trufakin] We found the peculiarities of the effects of dipeptidyl peptidase IV inhibitor diprotin A on immunological parameters of lymphocytes in lymphoid organs in intact animals and in animals with experimental autoimmune process. In intact animals, diprotin A increased cellularity of the thymus and spleen, number of CD4+, CD8+, and CD4+8+ thymocytes and CD3+ splenocytes and reduced cellularity of lymph nodes and the number of antibody-forming cells in the spleen. Diprotin A administered against the background of autoimmune process, reduced thymus cellularity, number of antibody-forming cells in the spleen, and number of CD4 and CD4+8+ thymocytes in comparison with the corresponding parameters of autoimmune process. Springer Science+Business Media New York, 2015 lymphocyte nationallicence diprotin A nationallicence experimental autoimmune process nationallicence Robinson M. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut Mel'nikova E. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut Trufakin V. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 769-771 0007-4888 158:6<769 2015 158 10517 https://doi.org/10.1007/s10517-015-2858-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2858-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Robinson M. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut NATIONALLICENCE 700 1- Mel'nikova E. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut NATIONALLICENCE 700 1- Trufakin V. Research Institute of Clinical and Experimental Lymphology, Siberian, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 769-771 0007-4888 158:6<769 2015 158 10517