caa a22 4500 60553747X CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2845-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2845-5 Ischemia in Pelvic Organs as an Independent Pathogenic Factor in the Development of Benign Prostatic Hyperplasia and Urinary Bladder Dysfunction [Elektronische Daten] [V. Kirpatovskii, I. Mudraya, K. Mkrtchyan, S. Revenko, G. Efremov, O. Nadtochii, I. Kabanova] Blood supply to the pelvic organs of outbred male rats was diminished by graduated constriction of the distal part of the inferior vena cava. Deficiency of intramural blood supply in prostate and urinary bladder was revealed by bioimpedance harmonic analysis according to the magnitude of first cardiac peak in the bioimpedance spectrogram. In 1-1.5 months, the histological examination revealed the glandular-stromal form of progressive benign prostatic hyperplasia in all ischemic rats. The development of hyperplasia was not accompanied by the changes in testosterone, dihydrotestosterone, or estradiol in blood and prostatic tissue. Assessment of vesical functional status by recording the intravesical pressure during infusion cystometry revealed an increase in the amplitude of spontaneous fluctuations of detrusor tone and intravesical pressure during bladder filling, which can be considered as indicator of detrusor hyperactivity. The data conclude that chronic ischemia of pelvic organs is an individual pathogenic factor in the development of benign prostatic hyperplasia and associated urinary disorders. Springer Science+Business Media New York, 2015 ischemia of pelvic organs nationallicence benign prostatic hyperplasia nationallicence urinary bladder hyperactivity nationallicence bioimpedance harmonic analysis nationallicence Kirpatovskii V. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Mudraya I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Mkrtchyan K. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Revenko S. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Efremov G. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Nadtochii O. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Kabanova I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 718-722 0007-4888 158:6<718 2015 158 10517 https://doi.org/10.1007/s10517-015-2845-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2845-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirpatovskii V. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Mudraya I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Mkrtchyan K. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Revenko S. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Efremov G. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Nadtochii O. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 700 1- Kabanova I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 718-722 0007-4888 158:6<718 2015 158 10517