caa a22 4500 605537488 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2850-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2850-8 Changes in Peripheral Blood Monocytes and Liver Macrophages in Male Rats after Benzo(a)pyrene Injection [Elektronische Daten] [S. Kolesnikov, S. Michurina, S. Arkhipov] Intraperitoneal injections of benzo(a)pyrene to male rats in a total dose of 60 mg/kg modified the production of ROS and the phagocytic potential of blood monocytes by modulating their potential bactericidal activity. The lysosomal system (particularly the secondary lysosomes) of liver macrophages was activated, which promoted fusion of the hydrolytic potentials of macrophages and monocytes. These results indicated that the toxin modulated the cellular immune homeostasis and the level of general nonspecific resistance. Springer Science+Business Media New York, 2015 liver nationallicence Kupffer's cells nationallicence monocytes nationallicence benzo(a)pyrene nationallicence phagocytic activity nationallicence Kolesnikov S. Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russia aut Michurina S. Research Institute of Clinical Immunology and Experimental Lymphology, Novosibirsk, Russia aut Arkhipov S. Research Institute of Clinical Immunology and Experimental Lymphology, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 735-738 0007-4888 158:6<735 2015 158 10517 https://doi.org/10.1007/s10517-015-2850-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2850-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolesnikov S. Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russia aut NATIONALLICENCE 700 1- Michurina S. Research Institute of Clinical Immunology and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Arkhipov S. Research Institute of Clinical Immunology and Experimental Lymphology, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 735-738 0007-4888 158:6<735 2015 158 10517