caa a22 4500 605537496 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2849-1 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2849-1 Low Doses of Hyperbaric Oxygenation Effectively Decrease the Size of Necrotic Zone in Rats with Experimental Myocardial Infarction [Elektronische Daten] [E. Dotsenko, N. Nikulina, D. Salivonchik, O. Lappo, A. Gritsuk, A. Bastron] We studied the effect of a single session of hyperbaric oxygenation on the size of risk, ischemic, and necrotic zones in rat myocardium after irreversible occlusion of the coronary artery and excessive oxygen pressure of 0.02 and 0.1 MPa. Myocardium infarction was reproduced by ligation of the left coronary artery. The size of the risk, ischemic, and necrotic zones was planimetrically evaluated. Hyperbaric oxygenation (60-min session) was performed 3 h after artery occlusion at excessive oxygen pressure of 0.02 and 0.1 MPa. In rats not exposed to hyperbaric oxygenation, the risk zone median was 31.7% of the left ventricle weight, while after the session it did not exceed 25%. In spontaneous course of myocardium infarction, the ischemia to necrosis zone ratio was 1.7:1, while under conditions of hyperbaric oxygenation at oxygen pressure of 0.1 and 0.02 MPa, the these values were 0.6:1 and 2:1, respectively. Excessive oxygen pressure of 0.02 mPa is better than traditionally used 0.1 MPa, because it promotes redistribution of the ischemic and necrotic areas in the risk zone: the area of necrotic zone decreased at the expense of the ischemic zone. Hyperbaric oxygenation produces a positive effect on the myocardium under conditions of total occlusion of the coronary artery. Springer Science+Business Media New York, 2015 hyperbaric oxygenation nationallicence experimental myocardium infarction nationallicence Dotsenko E. Belarussian State Medical University, Minsk, the Republic of Belarus aut Nikulina N. Belarussian State Medical University, Minsk, the Republic of Belarus aut Salivonchik D. Gomel State Medical University, Gomel, the Republic of Belarus aut Lappo O. Belarussian State Medical University, Minsk, the Republic of Belarus aut Gritsuk A. Gomel State Medical University, Gomel, the Republic of Belarus aut Bastron A. I. M. Seche nov Moscow State Medical University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 732-734 0007-4888 158:6<732 2015 158 10517 https://doi.org/10.1007/s10517-015-2849-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2849-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dotsenko E. Belarussian State Medical University, Minsk, the Republic of Belarus aut NATIONALLICENCE 700 1- Nikulina N. Belarussian State Medical University, Minsk, the Republic of Belarus aut NATIONALLICENCE 700 1- Salivonchik D. Gomel State Medical University, Gomel, the Republic of Belarus aut NATIONALLICENCE 700 1- Lappo O. Belarussian State Medical University, Minsk, the Republic of Belarus aut NATIONALLICENCE 700 1- Gritsuk A. Gomel State Medical University, Gomel, the Republic of Belarus aut NATIONALLICENCE 700 1- Bastron A. I. M. Seche nov Moscow State Medical University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 732-734 0007-4888 158:6<732 2015 158 10517