caa a22 4500 605537518 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2866-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2866-0 Age-Specific and Individual Features of Vasopressinergic Regulation of the Hypothalamic-Pituitary-Adrenal System in Primates [Elektronische Daten] [N. Goncharova, T. Oganyan, V. Marenin, A. Vengerin] Experimental study was carried out on young mature (6-8 years) and old (21-27 years) rhesus macaques with anxious and depression-like behavior and with standard (control) adaptive behavior. The responce of the adenohypophysis to arginine vasopressin depended on age and the type of adaptive behavior. Young animals with standard behavior demonstrated much higher concentrations of ACTH in the peripheral plasma in response to arginine vasopressin than old animals. The secretion of ACTH was higher in young and old animals with anxious and depressive-like adaptive behavior and they exhibited no age-specifi c differences in reaction to arginine vasopressin, which were observed in control animals. Preinjection of vasopressin V1b receptor antagonist to a female with high anxiety sharply reduced ACTH secretion in response to insulin-induced hypoglycemia in comparison with ACTH secretion under the same conditions without antagonist injection. These results suggested that the vasopressinergic system of animals with anxious and depressive behavior plays an important role in the regulation of ACTH secretion and in activity of the hypothalamic-pituitary-adrenal system in general. Springer Science+Business Media New York, 2015 arginine vasopressin nationallicence adrenocorticotropic hormone nationallicence adaptive behavior nationallicence aging nationallicence rhesus macaques nationallicence Goncharova N. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut Oganyan T. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut Marenin V. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut Vengerin A. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 804-806 0007-4888 158:6<804 2015 158 10517 https://doi.org/10.1007/s10517-015-2866-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2866-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goncharova N. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut NATIONALLICENCE 700 1- Oganyan T. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut NATIONALLICENCE 700 1- Marenin V. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut NATIONALLICENCE 700 1- Vengerin A. Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 804-806 0007-4888 158:6<804 2015 158 10517