caa a22 4500 605537534 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2870-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2870-4 Role of Subchondral Bone in the Restoration of Articular Cartilage [Elektronische Daten] [T. Stupina, M. Stepanov, M. Teplen'kii] The role of subchondral bone in the restoration of the articular cartilage was determined in experiments on mongrel dogs subjected to gonarthrosis modeling followed by subchondral zone tunneling and introduction of bone marrow suspension into the canal. Light microscopy, computer histomorphometry, and electron probe microanalysis showed that stimulation of functional activity of chondrocytes was achieved via correction of homeostasis of the cartilage and subchondral bone and improvement of tissue trophic. Restoration of the microarchitecture of the subchondral bone and improving its vascularization after tunneling with the introduction of bone marrow suspension into the drill holes enhances chondrocyte metabolism and recovers their functionality. Springer Science+Business Media New York, 2015 osteoarthrosis nationallicence subchondral bone nationallicence tunneling nationallicence articular cartilage nationallicence regeneration nationallicence Stupina T. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut Stepanov M. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut Teplen'kii M. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 820-823 0007-4888 158:6<820 2015 158 10517 https://doi.org/10.1007/s10517-015-2870-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2870-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stupina T. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut NATIONALLICENCE 700 1- Stepanov M. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut NATIONALLICENCE 700 1- Teplen'kii M. G. A. Ilizarov Russian Research Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation, Kurgan, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 820-823 0007-4888 158:6<820 2015 158 10517