caa a22 4500 605537550 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2855-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2855-3 Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives [Elektronische Daten] [I. Volchegorskii, I. Miroshnichenko, L. Rassokhina, R. Faizullin, M. Malkin, K. Pryakhina, A. Kalugina] Threefold administration of 3-hydroxypyridine derivatives emoxipine and mexidol in optimal doses corresponding to the therapeutic dose range for humans produced an anxiolytic effect and stimulated risk behavior in the elevated plus maze test in rats. These effects were most pronounced after injection of 3-hydroxypyridine derivative emoxipine. Combination of 3-hydroxypyridine cation and succinate anion in the mexidol structure led to attenuation of the anxiolytic effect and less pronounced stimulation of the risk behavior. By the anxiolytic effect and induction of risk behavior, emoxipine and mexidol were close to the reference substance amitriptyline. Reamberin, a succinic acid derivative, had no pronounced tranquilizing properties, but risk behavior induction was similar to that produced by mexidol. In contrast to other test agents, the reference substance α-lipoic acid produced anxiogenic effects and suppressed risk behavior. The obtained results suggest that Russian-made 3-hydroxypyridine derivatives emoxipine and mexidol are promising preparations for the treatment of anxiety disorders. Springer Science+Business Media New York, 2015 derivatives of 3-hydroxypyridine and succinic acid nationallicence anxiolytic activity nationallicence risk Behavior nationallicence Volchegorskii I. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Miroshnichenko I. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Rassokhina L. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Faizullin R. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Malkin M. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Pryakhina K. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Kalugina A. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 756-761 0007-4888 158:6<756 2015 158 10517 https://doi.org/10.1007/s10517-015-2855-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2855-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Volchegorskii I. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko I. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Rassokhina L. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Faizullin R. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Malkin M. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Pryakhina K. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Kalugina A. Department of Pharmacology, South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 756-761 0007-4888 158:6<756 2015 158 10517