caa a22 4500 605537593 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2863-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2863-3 PT/Y Mice Are Sensitive to the Inhibitory Effect of o -Aminoazotoluene on Glucocorticoid Induction of Tyrosine Aminotransferase and Its Hepatocarcinogenic Effect [Elektronische Daten] [T. Morozkova, L. Bogdanova, D. Semenov, N. Zhukova, N. Popova] PT/Y mice used for studies of the effects of mutagens are characterized by the absence of spontaneous tumors of the liver, but often develop these tumors in response to chronic oaminoazotoluene treatment. The level of glucocorticoid induction of adaptive hepatic enzyme tyrosine aminotransferase decreases by more than 70% 24h after acute injection of o-aminoazotoluene to these animals. These mice can serve as a model for studies of the relationship between the effect of carcinogens on the regulation of activity of adaptive hepatic enzymes and their capacity to induce the development of liver tumors. Springer Science+Business Media New York, 2015 PT / Y mice nationallicence o - aminoazotoluene nationallicence hepatocarcinogenic effect nationallicence Morozkova T. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bogdanova L. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Semenov D. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Zhukova N. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Popova N. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 789-793 0007-4888 158:6<789 2015 158 10517 https://doi.org/10.1007/s10517-015-2863-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2863-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morozkova T. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Bogdanova L. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Semenov D. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Zhukova N. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Popova N. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 789-793 0007-4888 158:6<789 2015 158 10517