caa a22 4500 605537607 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2853-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2853-5 Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy [Elektronische Daten] [M. Aleksandrova, N. Sirotina, O. Smirnova] Using immunohistochemical method with semiquantitative analysis of images, we showed that mrp2 expression in response to cholestasis decreased in hepatocytes and cholangiocytes, and remained unchanged in the kidney structures. A decrease of mrp2 expression in renal tubules leading to a decrease of metabolic intoxication of the kidney was demonstrated in cholestasis of pregnancy model. In bile ducts cells, negative correlations of mrp2 with previously measured levels of prolactin receptors, CFTR, and mrp3 were revealed. In renal structures and in hepatocytes, no correlations were found between the expression of these proteins. We hypothesize that prolactin produces a direct effect on mrp2 expression in bile ducts cells mediated by prolactin receptors in cholangiocytes. The absence of correlations between mrp2 and the above-mentioned proteins in hepatocytes and renal structures is most likely related to prolactin effects on other systemic regulators. Springer Science+Business Media New York, 2015 multidrug resistance protein 2 (mrp2) nationallicence prolactin receptor nationallicence cholestasis of pregnancy nationallicence liver nationallicence kidney nationallicence Aleksandrova M. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Sirotina N. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Smirnova O. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 748-752 0007-4888 158:6<748 2015 158 10517 https://doi.org/10.1007/s10517-015-2853-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2853-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aleksandrova M. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Sirotina N. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Smirnova O. Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 748-752 0007-4888 158:6<748 2015 158 10517