caa a22 4500 605537615 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2864-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2864-2 New Biomolecular Approaches to the Treatment of Glioblastoma Multiforme [Elektronische Daten] [I. Bryukhovetskii, A. Bryukhovetskii, Yu. Khotimchenko] The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientifi c theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personifi ed therapy of the glial tumors. A new approach to the treatment of glioblastoma multiforme with due consideration for the molecular biological characteristics of the tumor stem cells is suggested. It is shown that the tumor stem cell proteome can be regarded as the main target for cell therapy. Springer Science+Business Media New York, 2015 glioblastoma multiforme nationallicence stem cells nationallicence genomics nationallicence proteomics nationallicence transcriptomics nationallicence Bryukhovetskii I. School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut Bryukhovetskii A. School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut Khotimchenko Yu School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 794-799 0007-4888 158:6<794 2015 158 10517 https://doi.org/10.1007/s10517-015-2864-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2864-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bryukhovetskii I. School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut NATIONALLICENCE 700 1- Bryukhovetskii A. School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut NATIONALLICENCE 700 1- Khotimchenko Yu School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 794-799 0007-4888 158:6<794 2015 158 10517