caa a22 4500 605537631 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2847-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2847-3 Anxiolytic Effects of Gly-His-Lys Peptide and Its Analogs [Elektronische Daten] [I. Bobyntsev, O. Chernysheva, M. Dolgintsev, M. Smakhtin, A. Belykh] Intraperitoneal administration of tripeptide Gly-His-Lys to male rats in doses of 0.5, 5, and 50 μg/kg 12 min before the start of the experiment produced an anxiolytic effect in the elevated plus maze test manifested in an increase in the time spent in open arms and shortened time spent in the closed arms. The anxiolytic effect was most pronounced after injection of 0.5 μg/kg peptide and decreased with increasing the dose of the peptide. Replacement of L-lysine with D-lysine in the tripeptide molecule was accompanied by a significant weakening of the neurotropic effects in all studied doses. Attachment of D-alanine to N- or C-terminus of Gly-His-Lys peptide leveled its anxiolytic action in all doses; significant changes in some measures of increased anxiety after administration at 50 μg/kg were found. Springer Science+Business Media New York, 2015 regulatory peptides nationallicence anxiolytic effect nationallicence anxiety nationallicence behavior nationallicence Bobyntsev I. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Chernysheva O. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Dolgintsev M. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Smakhtin M. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Belykh A. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 726-728 0007-4888 158:6<726 2015 158 10517 https://doi.org/10.1007/s10517-015-2847-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2847-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bobyntsev I. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 700 1- Chernysheva O. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 700 1- Dolgintsev M. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 700 1- Smakhtin M. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 700 1- Belykh A. Department of Pathophysiology, Kursk State Medical University, Kursk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 726-728 0007-4888 158:6<726 2015 158 10517