caa a22 4500 60553764X CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2862-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2862-4 CCL19/CCL21-Dependent Chemotaxis of Dendritic Cells in Healthy Individuals and Patients with Brain Tumors [Elektronische Daten] [T. Tyrinova, O. Leplina, M. Tikhonova, S. Mishinov, V. Stupak, A. Ostanin, E. Chernykh] We compared migration activities of IFN-α- and IL-4-induced dendritic cells (IFN-DC and IL4-DC) generated from blood monocytes of healthy donors and analyzed migration activity of IFN-DC from patients with brain tumors. In the presence of CCL19 chemokine, donor IFN-DC exhibited higher migration activity than IL4-DC, the expression of chemokine CCR7-receptor being similar in the two cell types. IFN-DC of patients with malignant gliomas were characterized by low chemotaxis in response to CCL19 and CCL21 stimulation despite a trend to higher expression of CCR7 in comparison with donor IFN-DC. Springer Science+Business Media New York, 2015 dendritic cells nationallicence CCR7 nationallicence lymphoid chemokines nationallicence cerebral malignant gliomas nationallicence Tyrinova T. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Leplina O. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Tikhonova M. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Mishinov S. Research Institute of Traumatology and Orthopedics, Rosmedtechnologies, Novosibirsk, Russia aut Stupak V. Research Institute of Traumatology and Orthopedics, Rosmedtechnologies, Novosibirsk, Russia aut Ostanin A. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Chernykh E. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 785-788 0007-4888 158:6<785 2015 158 10517 https://doi.org/10.1007/s10517-015-2862-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2862-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tyrinova T. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Leplina O. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Tikhonova M. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Mishinov S. Research Institute of Traumatology and Orthopedics, Rosmedtechnologies, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Stupak V. Research Institute of Traumatology and Orthopedics, Rosmedtechnologies, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Ostanin A. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Chernykh E. Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 785-788 0007-4888 158:6<785 2015 158 10517