Inhibition of Secretory Activity of Atrial Myocytes in Hypertensive Rats after Losartan Treatment
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2746-7 |2 doi |
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| 245 | 0 | 0 | |a Inhibition of Secretory Activity of Atrial Myocytes in Hypertensive Rats after Losartan Treatment |h [Elektronische Daten] |c [V. Maksimov, I. Korostyshevskaya, A. Markel', G. Yakobson, N. Rudenko] |
| 520 | 3 | |a Male ISIAH rats with inherited stress-induced arterial hypertension (BP 174.0±1.3 mm Hg) received antagonist of angiotensin II receptors losartan in a dose of 10 mg/kg/day for 16 days. Ultrastructural study of the right atrium showed signs of dramatic and pronounced inhibition of synthesis of the natriuretic peptides (changes in the composition of secretory granules and decrease in their population density and size) the atrial myocytes against the background of persistent BP decrease in hypertensive rats to 142.0±4.2 mm Hg. We concluded that myoendocrine cells in rats with stable hypertension retain ability to respond adequately to distention of the atria with blood. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a arterial hypertension |2 nationallicence | |
| 690 | 7 | |a angiotensin receptor antagonists |2 nationallicence | |
| 690 | 7 | |a natriuretic peptides |2 nationallicence | |
| 690 | 7 | |a heart |2 nationallicence | |
| 690 | 7 | |a rat |2 nationallicence | |
| 700 | 1 | |a Maksimov |D V. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Korostyshevskaya |D I. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Markel' |D A. |u Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Yakobson |D G. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Rudenko |D N. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 301-303 |x 0007-4888 |q 158:3<301 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2746-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2746-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maksimov |D V. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Korostyshevskaya |D I. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Markel' |D A. |u Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yakobson |D G. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rudenko |D N. |u Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 301-303 |x 0007-4888 |q 158:3<301 |1 2015 |2 158 |o 10517 | ||