caa a22 4500 605537739 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2746-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2746-7 Inhibition of Secretory Activity of Atrial Myocytes in Hypertensive Rats after Losartan Treatment [Elektronische Daten] [V. Maksimov, I. Korostyshevskaya, A. Markel', G. Yakobson, N. Rudenko] Male ISIAH rats with inherited stress-induced arterial hypertension (BP 174.0±1.3 mm Hg) received antagonist of angiotensin II receptors losartan in a dose of 10 mg/kg/day for 16 days. Ultrastructural study of the right atrium showed signs of dramatic and pronounced inhibition of synthesis of the natriuretic peptides (changes in the composition of secretory granules and decrease in their population density and size) the atrial myocytes against the background of persistent BP decrease in hypertensive rats to 142.0±4.2 mm Hg. We concluded that myoendocrine cells in rats with stable hypertension retain ability to respond adequately to distention of the atria with blood. Springer Science+Business Media New York, 2015 arterial hypertension nationallicence angiotensin receptor antagonists nationallicence natriuretic peptides nationallicence heart nationallicence rat nationallicence Maksimov V. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Korostyshevskaya I. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Markel' A. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut Yakobson G. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Rudenko N. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 301-303 0007-4888 158:3<301 2015 158 10517 https://doi.org/10.1007/s10517-015-2746-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2746-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maksimov V. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Korostyshevskaya I. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Markel' A. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Yakobson G. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Rudenko N. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 301-303 0007-4888 158:3<301 2015 158 10517