caa a22 4500 605537763 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2751-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2751-x Neuroprotective and Antiamnesic Effect of Erythropoietin Derivatives after Experimental Ischemic Injury of Cerebral Cortex [Elektronische Daten] [G. Romanova, F. Shakova, I. Barskov, E. Stel'mashuk, E. Genrikhs, A. Cheremnykh, T. Kalinina, V. Yurin] Using the model of bilateral photothrombosis of the blood vessels in the prefrontal cortex we have shown that new hybrid proteins derived from recombinant human erythropoietin, carbamylated EPO-Fc and EPO-TR fusion proteins, injected intraperitoneally 1 h after ischemic injury contribute to restoration of passive avoidance response formed before photothrombotic injury and reduction in the volume of the ischemic focus. These data attest to nootropic and neuroprotective activities of these hybrid proteins. Carbamylated glycopeptide derivative ЕPO-TR exhibited prolonged neuroprotective properties. Springer Science+Business Media New York, 2015 hybrid proteins of erythropoietin nationallicence photothrombosis nationallicence prefrontal cortex nationallicence Romanova G. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Shakova F. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Barskov I. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Stel'mashuk E. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Genrikhs E. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Cheremnykh A. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut Kalinina T. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut Yurin V. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 318-321 0007-4888 158:3<318 2015 158 10517 https://doi.org/10.1007/s10517-015-2751-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2751-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Romanova G. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Shakova F. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Barskov I. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Stel'mashuk E. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Genrikhs E. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Cheremnykh A. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut NATIONALLICENCE 700 1- Kalinina T. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut NATIONALLICENCE 700 1- Yurin V. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 318-321 0007-4888 158:3<318 2015 158 10517