Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2749-4 |2 doi |
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| 245 | 0 | 0 | |a Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats |h [Elektronische Daten] |c [M. Azova, M. Blagonravov, V. Frolov] |
| 520 | 3 | |a We studied the effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats (SHR). Both drugs have no effect on the expression of Bcl-2, but significantly reduce the level of Bax protein (phosphocreatine produces more pronounced effect). These data attest to an important role of energy deficit and oxidative stress in the induction of cardiomyocyte apoptosis in genetically determined arterial hypertension. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a apoptosis |2 nationallicence | |
| 690 | 7 | |a hypertension |2 nationallicence | |
| 690 | 7 | |a cardiomyocyte |2 nationallicence | |
| 690 | 7 | |a phosphocreatine |2 nationallicence | |
| 690 | 7 | |a mexidol |2 nationallicence | |
| 700 | 1 | |a Azova |D M. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | |
| 700 | 1 | |a Blagonravov |D M. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | |
| 700 | 1 | |a Frolov |D V. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 313-314 |x 0007-4888 |q 158:3<313 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2749-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2749-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Azova |D M. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Blagonravov |D M. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Frolov |D V. |u Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 313-314 |x 0007-4888 |q 158:3<313 |1 2015 |2 158 |o 10517 | ||