caa a22 4500 60553778X CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2749-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2749-4 Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats [Elektronische Daten] [M. Azova, M. Blagonravov, V. Frolov] We studied the effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats (SHR). Both drugs have no effect on the expression of Bcl-2, but significantly reduce the level of Bax protein (phosphocreatine produces more pronounced effect). These data attest to an important role of energy deficit and oxidative stress in the induction of cardiomyocyte apoptosis in genetically determined arterial hypertension. Springer Science+Business Media New York, 2015 apoptosis nationallicence hypertension nationallicence cardiomyocyte nationallicence phosphocreatine nationallicence mexidol nationallicence Azova M. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut Blagonravov M. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut Frolov V. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 313-314 0007-4888 158:3<313 2015 158 10517 https://doi.org/10.1007/s10517-015-2749-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2749-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Azova M. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 700 1- Blagonravov M. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 700 1- Frolov V. Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 313-314 0007-4888 158:3<313 2015 158 10517