caa a22 4500 605537798 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2759-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2759-2 Nootropic Dipeptide Noopept Enhances Inhibitory Synaptic Transmission in the Hippocampus [Elektronische Daten] [I. Povarov, R. Kondratenko, V. Derevyagin, R. Ostrovskaya, V. Skrebitskii] Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component. A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found. The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons. Springer Science+Business Media New York, 2015 hippocampal slices nationallicence patch-clamp nationallicence Shaffer collaterals nationallicence Noopept nationallicence inhibitory interneurons nationallicence Povarov I. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Kondratenko R. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Derevyagin V. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Ostrovskaya R. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Skrebitskii V. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 349-351 0007-4888 158:3<349 2015 158 10517 https://doi.org/10.1007/s10517-015-2759-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2759-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Povarov I. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kondratenko R. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Derevyagin V. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Ostrovskaya R. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Skrebitskii V. Scientific Center for Neurology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 349-351 0007-4888 158:3<349 2015 158 10517