Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2750-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2750-y | ||
| 245 | 0 | 0 | |a Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration |h [Elektronische Daten] |c [M. Karpova, K. Zin'kovskii, L. Kuznetsova, N. Klishina] |
| 520 | 3 | |a We studied the dose-dependent effect of preventive intraperitoneal injection of citicoline (cytidine 5′-diphosphocholine) on acute generalized epileptiform activity in C57Bl/6 mice. The duration of citicoline action was also evaluated. Administration of citicoline in doses of 500 and 1000 mg/kg 1 h before treatment with the convulsant agent pentylenetetrazole produced an anticonvulsant effect. This effect was manifested in an increase of the threshold of clonic seizures and tonic phase of seizures with lethal outcome. Moreover, the latency of seizure development was elevated under these conditions. The anticonvulsant effect of citicoline persisted for 6 h after its injection. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a seizures |2 nationallicence | |
| 690 | 7 | |a pentylenetetrazole |2 nationallicence | |
| 690 | 7 | |a citicoline |2 nationallicence | |
| 700 | 1 | |a Karpova |D M. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Zin'kovskii |D K. |u Department of Psychiatry, Narcology, and Medical Psychology with the Course of Psychiatry, Tver State Medical Academy, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kuznetsova |D L. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Klishina |D N. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 315-317 |x 0007-4888 |q 158:3<315 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2750-y |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2750-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Karpova |D M. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zin'kovskii |D K. |u Department of Psychiatry, Narcology, and Medical Psychology with the Course of Psychiatry, Tver State Medical Academy, Ministry of Health of the Russian Federation, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuznetsova |D L. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Klishina |D N. |u Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 315-317 |x 0007-4888 |q 158:3<315 |1 2015 |2 158 |o 10517 | ||