caa a22 4500 605537801 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2750-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2750-y Increase of the Seizure Threshold in C57Bl/6 Mice after Citicoline Administration [Elektronische Daten] [M. Karpova, K. Zin'kovskii, L. Kuznetsova, N. Klishina] We studied the dose-dependent effect of preventive intraperitoneal injection of citicoline (cytidine 5′-diphosphocholine) on acute generalized epileptiform activity in C57Bl/6 mice. The duration of citicoline action was also evaluated. Administration of citicoline in doses of 500 and 1000 mg/kg 1 h before treatment with the convulsant agent pentylenetetrazole produced an anticonvulsant effect. This effect was manifested in an increase of the threshold of clonic seizures and tonic phase of seizures with lethal outcome. Moreover, the latency of seizure development was elevated under these conditions. The anticonvulsant effect of citicoline persisted for 6 h after its injection. Springer Science+Business Media New York, 2015 seizures nationallicence pentylenetetrazole nationallicence citicoline nationallicence Karpova M. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Zin'kovskii K. Department of Psychiatry, Narcology, and Medical Psychology with the Course of Psychiatry, Tver State Medical Academy, Ministry of Health of the Russian Federation, Moscow, Russia aut Kuznetsova L. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Klishina N. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 315-317 0007-4888 158:3<315 2015 158 10517 https://doi.org/10.1007/s10517-015-2750-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2750-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karpova M. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Zin'kovskii K. Department of Psychiatry, Narcology, and Medical Psychology with the Course of Psychiatry, Tver State Medical Academy, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kuznetsova L. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Klishina N. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 315-317 0007-4888 158:3<315 2015 158 10517