Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2766-3 |2 doi |
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| 245 | 0 | 0 | |a Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes |h [Elektronische Daten] |c [N. Ryazantseva, E. Stepovaya, O. Nosareva, E. Konovalova, D. Orlov, A. Naumova, S. Didenko, O. Vesnina, E. Shakhristova, A. Zima, V. Novitskii] |
| 520 | 3 | |a Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl) isoxazole (KRIBB3), a selective inhibitor of heat shock protein Hsp27. The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase, glutathione peroxidase, and realization of apoptotic death of Jurkat cells and blood lymphocytes. Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexin-positive cells. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cell redox status |2 nationallicence | |
| 690 | 7 | |a oxidative stress |2 nationallicence | |
| 690 | 7 | |a heat shock protein 27 |2 nationallicence | |
| 690 | 7 | |a tumor progression |2 nationallicence | |
| 690 | 7 | |a apoptosis |2 nationallicence | |
| 700 | 1 | |a Ryazantseva |D N. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Stepovaya |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Nosareva |D O. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Konovalova |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Orlov |D D. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Naumova |D A. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Didenko |D S. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Vesnina |D O. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Shakhristova |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Zima |D A. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Novitskii |D V. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 377-379 |x 0007-4888 |q 158:3<377 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2766-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2766-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ryazantseva |D N. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stepovaya |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nosareva |D O. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Konovalova |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Orlov |D D. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Naumova |D A. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Didenko |D S. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vesnina |D O. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shakhristova |D E. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zima |D A. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Novitskii |D V. |u Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 377-379 |x 0007-4888 |q 158:3<377 |1 2015 |2 158 |o 10517 | ||