caa a22 4500 605537836 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2766-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2766-3 Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes [Elektronische Daten] [N. Ryazantseva, E. Stepovaya, O. Nosareva, E. Konovalova, D. Orlov, A. Naumova, S. Didenko, O. Vesnina, E. Shakhristova, A. Zima, V. Novitskii] Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl) isoxazole (KRIBB3), a selective inhibitor of heat shock protein Hsp27. The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase, glutathione peroxidase, and realization of apoptotic death of Jurkat cells and blood lymphocytes. Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexin-positive cells. Springer Science+Business Media New York, 2015 cell redox status nationallicence oxidative stress nationallicence heat shock protein 27 nationallicence tumor progression nationallicence apoptosis nationallicence Ryazantseva N. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Stepovaya E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Nosareva O. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Konovalova E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Orlov D. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Naumova A. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Didenko S. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Vesnina O. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Shakhristova E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Zima A. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Novitskii V. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 377-379 0007-4888 158:3<377 2015 158 10517 https://doi.org/10.1007/s10517-015-2766-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2766-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryazantseva N. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Stepovaya E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Nosareva O. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Konovalova E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Orlov D. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Naumova A. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Didenko S. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Vesnina O. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Shakhristova E. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Zima A. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Novitskii V. Siberian State Medical University, the Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 377-379 0007-4888 158:3<377 2015 158 10517