caa a22 4500 605537860 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2764-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2764-5 Immunohistochemical Reactions of Primary Neuroendocrine Breast Cancer [Elektronische Daten] [M. Kirillina, K. Loskutova, A. Innokent'eva, E. Lushnikova, L. Nepomnyashchikh] We performed immunohistochemical analysis of neuroendocrine breast cancer. The significance of this approach to differential diagnosis of this cancer form by detection of specific markers is demonstrated. The incidence of diagnosis of neuroendocrine breast cancer has increased 8-fold over 5 years. Neuroendocrine breast cancer is responsible for 3.4% of all breast cancer cases. The disease is significantly more incident in patients over 60. Neuroendocrine breast cancer is characterized by high expression of neuron-specific enolase (100%) and chromagranin A (57%). The data indicate that irrespective of the location, macroscopic picture, and immunohistochemical profile of cytokeratins and steroid hormones, breast cancer is characterized by clear-cut expression of neuroendocrine markers in different combinations. Immunohistochemical detection of these markers makes it possible to detect the hormone-secreting elements and evaluate their role in the tumor pool, which is essential for the differential diagnosis of neuroendocrine breast cancer, including studies of puncture biopsy specimens. Springer Science+Business Media New York, 2015 neuroendocrine cancer nationallicence mammary gland nationallicence immunohistochemistry nationallicence Kirillina M. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Loskutova K. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Innokent'eva A. Medical Institute, M. K. Ammosov North Eastern Federal University, Yakutsk, Russia aut Lushnikova E. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Nepomnyashchikh L. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 368-370 0007-4888 158:3<368 2015 158 10517 https://doi.org/10.1007/s10517-015-2764-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2764-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirillina M. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Loskutova K. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Innokent'eva A. Medical Institute, M. K. Ammosov North Eastern Federal University, Yakutsk, Russia aut NATIONALLICENCE 700 1- Lushnikova E. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Nepomnyashchikh L. Yakut Scientific Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 368-370 0007-4888 158:3<368 2015 158 10517