caa a22 4500 605537887 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2765-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2765-4 Site-Directed Delivery of VEGF-Targeted Liposomes into Intracranial C6 Glioma [Elektronische Daten] [S. Shein, N. Nukolova, A. Korchagina, T. Abakumova, I. Kiuznetsov, M. Abakumov, V. Baklaushev, O. Gurina, V. Chekhonin] The efficiency of conventional chemotherapy for aggressive tumors in the CNS remains low and new strategies for the targeted delivery of anti-tumor substances are now actively developed. Pegylated liposomes covalently conjugated with monoclonal antibodies to VEGF synthesized by us are nanoparticle characterized by narrow size distribution and high dispersion stability. Immunochemical activity of antibodies after conjugation was 70% of initial level. The anti-VEGF liposomes developed by us were highly specific for VEGF+ tumor cells (in vitro and in vivo). Intravenous injection of VEGF-liposomes to rats with intracranial C6 glioma was followed by their specific accumulation in the malignant tissues and engulfment by glioma cells, which attested to target delivery and selective accumulation of anti-VEGF-liposomes in the brain tumor. Thus, the use of targeting molecules can significantly increase the distribution and efficiency of delivery of nanocontainers to a tumor characterized by hyperexpression of the target proteins. Springer Science+Business Media New York, 2015 vascular endothelial growth factor (VEGF) nationallicence target delivery nationallicence liposomes nationallicence monoclonal antibodies nationallicence brain tumors nationallicence Shein S. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Nukolova N. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Korchagina A. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Abakumova T. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Kiuznetsov I. Department of Chemical Enzymology, Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Abakumov M. Department of Medical Nanobiotechnology, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Baklaushev V. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Gurina O. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Chekhonin V. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 371-376 0007-4888 158:3<371 2015 158 10517 https://doi.org/10.1007/s10517-015-2765-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2765-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shein S. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Nukolova N. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Korchagina A. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Abakumova T. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kiuznetsov I. Department of Chemical Enzymology, Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Abakumov M. Department of Medical Nanobiotechnology, Medical and Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Baklaushev V. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Gurina O. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Chekhonin V. Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Scientific Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 371-376 0007-4888 158:3<371 2015 158 10517