caa a22 4500 605537895 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2758-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2758-3 Effects of Hydroxypyridine Derivatives Mexidol and Emoxypin on the Reparative Processes in Rabbit Eye on the Models of Corneal Epithelial Defect and Conjunctival Ischemia [Elektronische Daten] [N. Chesnokova, O. Beznos, T. Pavlenko, A. Zabozlaev, M. Pavlova] Deepithelialization of the cornea (diameter 7 mm) was performed in rabbits and the rate of defect epithelialization was evaluated. Conjunctival ischemia was modeled by application of graduated alkaline burn. Antioxidant activity and content of nitrates and nitrites was measured in the tear fluid before and after burn by chemiluminescence and Griess methods, respectively. Emoxypin and mexidol promoted healing of corneal epithelial defect at the stage of epitheliocyte migration to the defect area and at the stage of their proliferation, respectively. After treatment with both agents, the area of conjunctival ischemia decreased more rapidly, but the efficiency of mexidol was higher. Antioxidant activity and content of products of NO metabolism in tear fluid decreased after burn. Mexidol, but not emoxypin, increased these parameters. Thus, mexidol and emoxypin have different effects on corneal epithelialization and conjunctival ischemia and effects of mexidol are more pronounced. Springer Science+Business Media New York, 2015 Mexidol nationallicence corneal epithelial defect nationallicence eye burns nationallicence antioxidant activity nationallicence nitrogen oxide nationallicence Chesnokova N. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Beznos O. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Pavlenko T. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Zabozlaev A. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Pavlova M. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 346-348 0007-4888 158:3<346 2015 158 10517 https://doi.org/10.1007/s10517-015-2758-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2758-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chesnokova N. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Beznos O. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Pavlenko T. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Zabozlaev A. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Pavlova M. Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 346-348 0007-4888 158:3<346 2015 158 10517