Role of Cholesterol in the Maintenance of Endplate Electrogenesis in Rat Diaphragm
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| 245 | 0 | 0 | |a Role of Cholesterol in the Maintenance of Endplate Electrogenesis in Rat Diaphragm |h [Elektronische Daten] |c [V. Kravtsova, A. Petrov, A. Vasil'ev, A. Zefirov, I. Krivoi] |
| 520 | 3 | |a Methyl-β-cyclodextrin (0.1 mM) reduced resting potential of muscle fibers and abolished local endplate membrane hyperpolarization in rat diaphragm. This effect was associated with selective reduction of electrogenic activity of α2-isoform of Na,K-ATPase without changes in the level of intracellular acetylcholine. Experiments with cholesterol marker filipin showed that methyl-β-cyclodextrin in this dose induced cholesterol translocation from lipid rafts to liquid phase of the membrane without its release into extracellular space. This modification of lipid rafts by methyl-β-cyclodextrin presumably impaired the mechanism maintaining electrogenesis in endplates mediated by modulation of Na,K-ATPase by non-quantum acetylcholine. Cholesterol can serve as a molecular component of this mechanism. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cholesterol |2 nationallicence | |
| 690 | 7 | |a lipid rafts |2 nationallicence | |
| 690 | 7 | |a Na,K-ATPase |2 nationallicence | |
| 690 | 7 | |a acetylcholine |2 nationallicence | |
| 700 | 1 | |a Kravtsova |D V. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Petrov |D A. |u Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia |4 aut | |
| 700 | 1 | |a Vasil'ev |D A. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Zefirov |D A. |u Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia |4 aut | |
| 700 | 1 | |a Krivoi |D I. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 298-300 |x 0007-4888 |q 158:3<298 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2745-8 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2745-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kravtsova |D V. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petrov |D A. |u Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vasil'ev |D A. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zefirov |D A. |u Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Krivoi |D I. |u Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 298-300 |x 0007-4888 |q 158:3<298 |1 2015 |2 158 |o 10517 | ||