caa a22 4500 605537933 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2753-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2753-8 Ca2+ Ions Regulate Activity of Na+,Cl-(HCO 3 − )-ATPase in the Mucosa of Rabbit Small Intestine [Elektronische Daten] [V. Yurkiv, V. Melikhov, V. Shubin] We studied the effects of bivalent metal ions on activity of Na+,Cl-(HCO3 -)-ATPase was studied. In contrast to Ba2+, Co2+, Zn2+, and Mn2+ ions, Ca2+ and Mg2+ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+,Cl-(HCO3 -)-ATPase. A possible mechanism of regulation of enzyme activity by Ca2+ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl- ions was proposed. Springer Science+Business Media New York, 2015 secretory process nationallicence small intestine nationallicence transport ATPase nationallicence CFTR nationallicence Yurkiv V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut Melikhov V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut Shubin V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 326-328 0007-4888 158:3<326 2015 158 10517 https://doi.org/10.1007/s10517-015-2753-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2753-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yurkiv V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut NATIONALLICENCE 700 1- Melikhov V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut NATIONALLICENCE 700 1- Shubin V. Laboratory of Molecular Mechanisms for Infections, Central Research Institute of Epidemiology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 326-328 0007-4888 158:3<326 2015 158 10517