Serum, Liver, and Lung Levels of the Major Extracellular Matrix Components at the Early Stage of BCG-Induced Granulomatosis Depending on the Infection Route
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2752-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2752-9 | ||
| 245 | 0 | 0 | |a Serum, Liver, and Lung Levels of the Major Extracellular Matrix Components at the Early Stage of BCG-Induced Granulomatosis Depending on the Infection Route |h [Elektronische Daten] |c [L. Kim, V. Shkurupy, A. Putyatina] |
| 520 | 3 | |a Experiments on the model of mouse BCG-induced granulomatous showed that the content of glycosaminoglycans and proteoglycans in the extracellular matrix of the liver and lungs are changed at the early stages of inflammation (days 3 and 30 postinfection) before cell destruction in the organs begins. This is related to degradation of extracellular matrix structures. Their high content in the blood and interstitium probably contributes to the formation of granulomas, fibroblast proliferation and organ fibrosis. These processes depend on the infection route that determines different conditions for generalization of the inflammation process. Intravenous method of vaccine injection is preferable to use when designing the experiments simulating tuberculosis granulomatosis, especially for the analysis of its early stages. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a BCG granulomatosis |2 nationallicence | |
| 690 | 7 | |a inoculation route |2 nationallicence | |
| 690 | 7 | |a mice |2 nationallicence | |
| 690 | 7 | |a glycosaminoglycans |2 nationallicence | |
| 690 | 7 | |a hydroxyproline |2 nationallicence | |
| 700 | 1 | |a Kim |D L. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Shkurupy |D V. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Putyatina |D A. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 322-325 |x 0007-4888 |q 158:3<322 |1 2015 |2 158 |o 10517 | |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2752-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D L. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shkurupy |D V. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Putyatina |D A. |u Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 322-325 |x 0007-4888 |q 158:3<322 |1 2015 |2 158 |o 10517 | ||