caa a22 4500 605537976 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2752-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2752-9 Serum, Liver, and Lung Levels of the Major Extracellular Matrix Components at the Early Stage of BCG-Induced Granulomatosis Depending on the Infection Route [Elektronische Daten] [L. Kim, V. Shkurupy, A. Putyatina] Experiments on the model of mouse BCG-induced granulomatous showed that the content of glycosaminoglycans and proteoglycans in the extracellular matrix of the liver and lungs are changed at the early stages of inflammation (days 3 and 30 postinfection) before cell destruction in the organs begins. This is related to degradation of extracellular matrix structures. Their high content in the blood and interstitium probably contributes to the formation of granulomas, fibroblast proliferation and organ fibrosis. These processes depend on the infection route that determines different conditions for generalization of the inflammation process. Intravenous method of vaccine injection is preferable to use when designing the experiments simulating tuberculosis granulomatosis, especially for the analysis of its early stages. Springer Science+Business Media New York, 2015 BCG granulomatosis nationallicence inoculation route nationallicence mice nationallicence glycosaminoglycans nationallicence hydroxyproline nationallicence Kim L. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Shkurupy V. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Putyatina A. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 322-325 0007-4888 158:3<322 2015 158 10517 https://doi.org/10.1007/s10517-015-2752-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2752-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim L. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shkurupy V. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Putyatina A. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 322-325 0007-4888 158:3<322 2015 158 10517