caa a22 4500 605537984 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2747-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2747-6 Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment [Elektronische Daten] [A. Dygai, V. Zhdanov, L. Miroshnichenko, E. Udut, G. Zyuz'kov, E. Simanina, A. Chaikovskii, L. Stavrova, E. Trofimova, Ya. Burmina] We studied the role of signaling pathways in the regulation of erythropoiesis against the background of myelosuppression caused by administration of 5-fluorouracil. The important role of cyclic AMP in the maturation of erythroid progenitors after cytostatic treatment was demonstrated. The secretory activity of myelokaryocytes during the period of erythroid hemopoiesis recovery is mainly regulated via the p38 MAPK signaling pathway; non-erythropoietin factors are involved in the formation of erythropoietic activity of adherent cells of the microenvironment. Springer Science+Business Media New York, 2015 NF-κB nationallicence protein kinase p38 nationallicence adenylatecyclase nationallicence myelosuppression nationallicence erythropoietin nationallicence Dygai A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Zhdanov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Udut E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Simanina E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Stavrova L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Trofimova E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Burmina Ya E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 304-307 0007-4888 158:3<304 2015 158 10517 https://doi.org/10.1007/s10517-015-2747-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2747-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dygai A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Zhdanov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Simanina E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Stavrova L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Trofimova E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Burmina Ya E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 304-307 0007-4888 158:3<304 2015 158 10517