caa a22 4500 60553800X CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2755-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2755-6 Mdm2-Dependent Regulation of p53 Expression during Long-Term Potentiation [Elektronische Daten] [P. Lisachev, V. Pustylnyak, M. Shtark] Induction of long-term posttetanic potentiation in rat hippocampal CA1 filed was followed by a decrease in the content of transcription factor p53 against the background of unchanged level of p53 mRNA, which implies activation of negative regulators of p53. Mdm2 is an important regulator of p53. We studied the effects of Mdm2 inhibitor nutlin-3 on p53 expression during generation of long-term posttetanic potentiation. Mdm2 inhibition completely prevented tetanization-induced decrease in the content of p53 protein; the level of p53 mRNA tended to increase in 30 min after tetanization. Thus, Mdm2 contributes to the maintenance of constant level of mRNA and plays a pivotal role in the decrease in the level of p53 protein during induction of long-term potentiation. Springer Science+Business Media New York, 2015 long-term potentiation nationallicence CA1 nationallicence p53 nationallicence Mdm-2 nationallicence nutlin-3 nationallicence Lisachev P. Designing and Technological Institute of Computer Engineering, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut Pustylnyak V. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut Shtark M. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 333-335 0007-4888 158:3<333 2015 158 10517 https://doi.org/10.1007/s10517-015-2755-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2755-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lisachev P. Designing and Technological Institute of Computer Engineering, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Pustylnyak V. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shtark M. Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 333-335 0007-4888 158:3<333 2015 158 10517