Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2756-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2756-5 | ||
| 245 | 0 | 0 | |a Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol |h [Elektronische Daten] |c [D. Semenov, N. Zhukova, E. Ivanova, I. Sorokina, D. Baiev, G. Nepomnyashchikh, T. Tolstikova, M. Biryukova] |
| 520 | 3 | |a Toxic liver injury with the development of fi brosis and cirrhosis was modeled in Wistar rats by intragastric administration of 0.1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks. The animals were treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It was found that betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a signifi cant decrease in the severity of liver fi brosis and the absence of cirrhotic transformation of the liver. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a toxic liver injury |2 nationallicence | |
| 690 | 7 | |a cirrhosis |2 nationallicence | |
| 690 | 7 | |a cytoprotection |2 nationallicence | |
| 690 | 7 | |a carbon tetrachloride |2 nationallicence | |
| 690 | 7 | |a betulonic acid amide |2 nationallicence | |
| 700 | 1 | |a Semenov |D D. |u Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Zhukova |D N. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Ivanova |D E. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Sorokina |D I. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Baiev |D D. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Nepomnyashchikh |D G. |u Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Tolstikova |D T. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Biryukova |D M. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 336-341 |x 0007-4888 |q 158:3<336 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2756-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2756-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semenov |D D. |u Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhukova |D N. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ivanova |D E. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sorokina |D I. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baiev |D D. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nepomnyashchikh |D G. |u Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tolstikova |D T. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Biryukova |D M. |u N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/3(2015-01-01), 336-341 |x 0007-4888 |q 158:3<336 |1 2015 |2 158 |o 10517 | ||