caa a22 4500 605538018 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10517-015-2756-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2756-5 Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol [Elektronische Daten] [D. Semenov, N. Zhukova, E. Ivanova, I. Sorokina, D. Baiev, G. Nepomnyashchikh, T. Tolstikova, M. Biryukova] Toxic liver injury with the development of fi brosis and cirrhosis was modeled in Wistar rats by intragastric administration of 0.1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks. The animals were treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It was found that betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a signifi cant decrease in the severity of liver fi brosis and the absence of cirrhotic transformation of the liver. Springer Science+Business Media New York, 2015 toxic liver injury nationallicence cirrhosis nationallicence cytoprotection nationallicence carbon tetrachloride nationallicence betulonic acid amide nationallicence Semenov D. Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut Zhukova N. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Ivanova E. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Sorokina I. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Baiev D. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Nepomnyashchikh G. Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut Tolstikova T. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Biryukova M. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 336-341 0007-4888 158:3<336 2015 158 10517 https://doi.org/10.1007/s10517-015-2756-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2756-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Semenov D. Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Zhukova N. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Ivanova E. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Sorokina I. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Baiev D. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Nepomnyashchikh G. Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Tolstikova T. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Biryukova M. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/3(2015-01-01), 336-341 0007-4888 158:3<336 2015 158 10517