Chronodependent Effect of Interleukin-2 on Mouse Spleen Cells in the Model of Cyclophosphamide Immunosuppression
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2787-y |2 doi |
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| 245 | 0 | 0 | |a Chronodependent Effect of Interleukin-2 on Mouse Spleen Cells in the Model of Cyclophosphamide Immunosuppression |h [Elektronische Daten] |c [A. Shurlygina, E. Mel'nikova, V. Trufakin] |
| 520 | 3 | |a We studied the chronodependent effect of IL-2 in the experimental model of immunodeficiency, cyclophosphamide-induced immunosuppression in mice. IL-2 in a dose of 100 U/ mouse was administered at 10.00 and 16.00 for 3 days after injection of cyclophosphamide. In contrast to the morning treatment with the cytokine, evening administration produced antiapoptotic effect on splenocytes and stimulated proliferation to a greater extent. This was accompanied by an increase in the number of CD4+, CD25+ and CD4+25+ cells in the spleen to a level of intact mice. More pronounced effect of the evening mode of IL-2 administration on the proliferation and subpopulation composition of mouse spleen cells in the studied model can be associated with high blood level of CD25+ cells at this time of the day. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a interleukin-2 |2 nationallicence | |
| 690 | 7 | |a cyclophosphamide |2 nationallicence | |
| 690 | 7 | |a biorhythms |2 nationallicence | |
| 690 | 7 | |a spleen cells |2 nationallicence | |
| 700 | 1 | |a Shurlygina |D A. |u Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Mel'nikova |D E. |u Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Trufakin |D V. |u Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 471-474 |x 0007-4888 |q 158:4<471 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2787-y |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2787-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shurlygina |D A. |u Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mel'nikova |D E. |u Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Trufakin |D V. |u Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 471-474 |x 0007-4888 |q 158:4<471 |1 2015 |2 158 |o 10517 | ||