caa a22 4500 605538034 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10517-015-2787-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2787-y Chronodependent Effect of Interleukin-2 on Mouse Spleen Cells in the Model of Cyclophosphamide Immunosuppression [Elektronische Daten] [A. Shurlygina, E. Mel'nikova, V. Trufakin] We studied the chronodependent effect of IL-2 in the experimental model of immunodeficiency, cyclophosphamide-induced immunosuppression in mice. IL-2 in a dose of 100 U/ mouse was administered at 10.00 and 16.00 for 3 days after injection of cyclophosphamide. In contrast to the morning treatment with the cytokine, evening administration produced antiapoptotic effect on splenocytes and stimulated proliferation to a greater extent. This was accompanied by an increase in the number of CD4+, CD25+ and CD4+25+ cells in the spleen to a level of intact mice. More pronounced effect of the evening mode of IL-2 administration on the proliferation and subpopulation composition of mouse spleen cells in the studied model can be associated with high blood level of CD25+ cells at this time of the day. Springer Science+Business Media New York, 2015 interleukin-2 nationallicence cyclophosphamide nationallicence biorhythms nationallicence spleen cells nationallicence Shurlygina A. Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia aut Mel'nikova E. Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia aut Trufakin V. Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 471-474 0007-4888 158:4<471 2015 158 10517 https://doi.org/10.1007/s10517-015-2787-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2787-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shurlygina A. Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Mel'nikova E. Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Trufakin V. Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 471-474 0007-4888 158:4<471 2015 158 10517