Role of Peptide Bond in the Realization of Biological Activity of Short Peptides
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2805-0 |2 doi |
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| 245 | 0 | 0 | |a Role of Peptide Bond in the Realization of Biological Activity of Short Peptides |h [Elektronische Daten] |c [V. Khavinson, S. Tarnovskaya, N. Lin'kova, N. Chervyakova, T. Nichik, E. Elashkina, N. Chalisova] |
| 520 | 3 | |a We performed a comparative analysis of biological activity of Lys-Glu peptide and its amino acid constituents. It was established that Lys-Glu stimulated proliferation of splenic cells in organotypic culture, while the mixture of glutamic acid and lysine inhibited culture growth. Using the method of molecular docking, we showed that glutamic acid, lysine, and Lys-Glu peptide can interact with different DNA sequences. The energy of interaction and the most beneficial localization of glutamic acid, lysine, and Lys-Glu peptide in DNA molecule was calculated. We demonstrated the interaction of the peptide and amino acids with DNA along the minor groove. The energy of DNA interaction with the peptide is higher than with individual amino acids. The peptide bonds increase the interaction of Lys-Glu peptide with DNA, which potentiates the biological effect on cell proliferation in organotypic culture of splenic cells. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a dipeptide |2 nationallicence | |
| 690 | 7 | |a amino acids |2 nationallicence | |
| 690 | 7 | |a molecular modeling |2 nationallicence | |
| 690 | 7 | |a docking |2 nationallicence | |
| 690 | 7 | |a organotypic culture |2 nationallicence | |
| 700 | 1 | |a Khavinson |D V. |u I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Tarnovskaya |D S. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Lin'kova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Chervyakova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Nichik |D T. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Elashkina |D E. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Chalisova |D N. |u I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 551-554 |x 0007-4888 |q 158:4<551 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2805-0 |q text/html |z Onlinezugriff via DOI |
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| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2805-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khavinson |D V. |u I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tarnovskaya |D S. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lin'kova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chervyakova |D N. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nichik |D T. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Elashkina |D E. |u St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chalisova |D N. |u I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 551-554 |x 0007-4888 |q 158:4<551 |1 2015 |2 158 |o 10517 | ||