Expression of Ryanodine Receptor mRNA and Sarcoplasmic Ca2+-ATPase mRNA in the Myocardium and Intracellular Reorganization of Cardiomyocytes in Dyslipidemia and during Verapamil Treatment
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2804-1 |2 doi |
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| 245 | 0 | 0 | |a Expression of Ryanodine Receptor mRNA and Sarcoplasmic Ca2+-ATPase mRNA in the Myocardium and Intracellular Reorganization of Cardiomyocytes in Dyslipidemia and during Verapamil Treatment |h [Elektronische Daten] |c [E. Yuzhik, E. Lushnikova, M. Klinnikova, V. Pichigin, L. Nepomnyashchikh] |
| 520 | 3 | |a In experiments on rats, atherogenic diet led to hypercholesterolemia, while addition of verapamil to the diet led to the development of hypertriglyceridemia in these animals. Dyslipidemia induced signifi cant changes in the cardiomyocyte ultrastructure (lytic changes in myofi brils and sarcoplasmic matrix and aggravation of autophagocytosis) that were most pronounced after addition of mercazolyl alone to the diet. After 30-day atherogenic diet, we observed a decrease in the relative content of RyR2 mRNA (by 67-73%, p<0.01) and SERCA2a mRNA (by 75-91%, p<0.01) in the myocardium. In 64 days these parameters remained reduced: by 64-72% (p<0.05) and 54-62% (p<0.05), respectively. Verapamil treatment reduced the severity and number of lytic lesions in cardiomyocytes, induced considerable glycogen accumulation in the sarcoplasm and its sequestration, promoted normalization, and prevented pronounced decrease of the relative RyR2 mRNA and SERCA2a mRNA in rat myocardium. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a dyslipidemia |2 nationallicence | |
| 690 | 7 | |a cardiomyocyte ultrastructure |2 nationallicence | |
| 690 | 7 | |a verapamil |2 nationallicence | |
| 690 | 7 | |a Ca 2+ transport |2 nationallicence | |
| 690 | 7 | |a electron microscopy |2 nationallicence | |
| 700 | 1 | |a Yuzhik |D E. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Lushnikova |D E. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Klinnikova |D M. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Pichigin |D V. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Nepomnyashchikh |D L. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 544-550 |x 0007-4888 |q 158:4<544 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2804-1 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2804-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yuzhik |D E. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lushnikova |D E. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Klinnikova |D M. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pichigin |D V. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nepomnyashchikh |D L. |u Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 544-550 |x 0007-4888 |q 158:4<544 |1 2015 |2 158 |o 10517 | ||