caa a22 4500 605538085 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10517-015-2793-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2793-0 P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation [Elektronische Daten] [A. Trashkov, A. Panchenko, E. Kayukova, R. Korablev, V. Pechatnikova, A. Vasil'ev, V. Anisimov] Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. Springer Science+Business Media New York, 2015 tumor nationallicence hemostasis nationallicence neoangiogenesis nationallicence vascular endothelial growth factor nationallicence P-388 leukemia nationallicence Trashkov A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Panchenko A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Kayukova E. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Korablev R. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Pechatnikova V. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Vasil'ev A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Anisimov V. N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 497-499 0007-4888 158:4<497 2015 158 10517 https://doi.org/10.1007/s10517-015-2793-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2793-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trashkov A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Panchenko A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Kayukova E. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Korablev R. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Pechatnikova V. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Vasil'ev A. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Anisimov V. N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 497-499 0007-4888 158:4<497 2015 158 10517