caa a22 4500 605538174 CHVBK 20210128100900.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10517-015-2785-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2785-0 Effects of Immunomodulators on Functional Activity of Innate Immunity Cells Infected with Streptococcus pneumoniae [Elektronische Daten] [N. Plekhova, N. Kondrashova, L. Somova, E. Drobot, I. Lyapun] Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia. The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis. Analysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia. Springer Science+Business Media New York, 2015 innate immunity cells nationallicence Streptococcus pneumonia nationallicence immunomodulators nationallicence antibiotics nationallicence Apoptosis nationallicence Plekhova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut Kondrashova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut Somova L. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut Drobot E. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut Lyapun I. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 461-464 0007-4888 158:4<461 2015 158 10517 https://doi.org/10.1007/s10517-015-2785-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2785-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Plekhova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Kondrashova N. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Somova L. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Drobot E. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut NATIONALLICENCE 700 1- Lyapun I. G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 461-464 0007-4888 158:4<461 2015 158 10517