caa a22 4500 605538239 CHVBK 20210128100901.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10517-015-2811-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2811-2 Effect of Cerebral Ischemia on Redox Status of Plasma Aminothiols [Elektronische Daten] [A. Ivanov, V. Aleksandrin, B. Luzyanin, A. Kubatiev] We measured the content of reduced aminothiols (cysteine, homocysteine, and glutathione) after mechanical occlusion of the middle cerebral artery in rats. During acute period of ischemia (3 h), these parameters decreased by ~10 times. In 7 days, the content of reduced aminothiols in some animals remained low, but in the others surpassed the initial levels. These results indicate significant impairment of the redox status of the circulating aminothiol pool apparently caused by oxidative stress of the peripheral vascular endothelial occurring as a response to cerebral ischemia. Thus, the total amount of homocysteine is considered a risk factor for stroke, while its reduced fraction can reflect the post stroke state. Springer Science+Business Media New York, 2015 aminothiols nationallicence cerebral ischemia nationallicence high performance liquid chromatography nationallicence dithionitrobenzoic acid nationallicence Ivanov A. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Aleksandrin V. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Luzyanin B. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Kubatiev A. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 413-416 0007-4888 158:4<413 2015 158 10517 https://doi.org/10.1007/s10517-015-2811-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2811-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ivanov A. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Aleksandrin V. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Luzyanin B. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kubatiev A. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 413-416 0007-4888 158:4<413 2015 158 10517