Possible Role and Application of fMRI in the Screening of Release-Active Drugs
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2783-2 |2 doi |
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| 245 | 0 | 0 | |a Possible Role and Application of fMRI in the Screening of Release-Active Drugs |h [Elektronische Daten] |c [S. Duma, M. Rezakova, K. Mazhirina, E. Petrovskii, M. Pokrovskii, O. Dzhafarova, A. Savelov, M. Shtark, O. Epstein] |
| 520 | 3 | |a Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution. In the treatment group (in contrast to placebo), active zones in these structures were found only during task solution. Thus, resolution capability of fMRI significantly extends the range of rational screening by identifying active zones and can radically change the procedure of selection and clinical trials. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a release-active neuroprotective drugs |2 nationallicence | |
| 690 | 7 | |a release-active forms |2 nationallicence | |
| 690 | 7 | |a functional magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a neuroimaging |2 nationallicence | |
| 690 | 7 | |a cognitive properties |2 nationallicence | |
| 700 | 1 | |a Duma |D S. |u Research Institute of Therapy and Preventative Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Rezakova |D M. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Mazhirina |D K. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Petrovskii |D E. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Pokrovskii |D M. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Dzhafarova |D O. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Savelov |D A. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Shtark |D M. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Epstein |D O. |u Materia Medica Holding, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 453-457 |x 0007-4888 |q 158:4<453 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2783-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2783-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Duma |D S. |u Research Institute of Therapy and Preventative Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rezakova |D M. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mazhirina |D K. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petrovskii |D E. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pokrovskii |D M. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dzhafarova |D O. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Savelov |D A. |u International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shtark |D M. |u Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Epstein |D O. |u Materia Medica Holding, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/4(2015-02-01), 453-457 |x 0007-4888 |q 158:4<453 |1 2015 |2 158 |o 10517 | ||