caa a22 4500 605538379 CHVBK 20210128100901.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10517-015-2783-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2783-2 Possible Role and Application of fMRI in the Screening of Release-Active Drugs [Elektronische Daten] [S. Duma, M. Rezakova, K. Mazhirina, E. Petrovskii, M. Pokrovskii, O. Dzhafarova, A. Savelov, M. Shtark, O. Epstein] Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution. In the treatment group (in contrast to placebo), active zones in these structures were found only during task solution. Thus, resolution capability of fMRI significantly extends the range of rational screening by identifying active zones and can radically change the procedure of selection and clinical trials. Springer Science+Business Media New York, 2015 release-active neuroprotective drugs nationallicence release-active forms nationallicence functional magnetic resonance imaging nationallicence neuroimaging nationallicence cognitive properties nationallicence Duma S. Research Institute of Therapy and Preventative Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Rezakova M. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Mazhirina K. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Petrovskii E. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Pokrovskii M. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Dzhafarova O. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Savelov A. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Shtark M. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Epstein O. Materia Medica Holding, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 453-457 0007-4888 158:4<453 2015 158 10517 https://doi.org/10.1007/s10517-015-2783-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2783-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duma S. Research Institute of Therapy and Preventative Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Rezakova M. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Mazhirina K. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Petrovskii E. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Pokrovskii M. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Dzhafarova O. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Savelov A. International Tomography Center, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shtark M. Research Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Epstein O. Materia Medica Holding, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/4(2015-02-01), 453-457 0007-4888 158:4<453 2015 158 10517