Autoantibodies to Plasminogen and Their Role in Tumor Diseases

Verfasser / Beitragende:
[E. Goufman, V. Yakovlev, N. Tikhonova, R. Aisina, K. Yarygin, L. Mukhametova, K. Gershkovich, D. Gulin]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 158/4(2015-02-01), 493-496
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2792-1  |2 doi 
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245 0 0 |a Autoantibodies to Plasminogen and Their Role in Tumor Diseases  |h [Elektronische Daten]  |c [E. Goufman, V. Yakovlev, N. Tikhonova, R. Aisina, K. Yarygin, L. Mukhametova, K. Gershkovich, D. Gulin] 
520 3 |a Plasma level of IgG autoantibodies to plasminogen was measured by ELISA in patients with benign prostatic hyperplasia (n=25), prostatic cancer (n=17), lung cancer (n=15), and healthy volunteers (n=44). High levels of IgG to plasminogen were found in 2 (12%) of 17 healthy women, in 1 (3.6%) of 27 specimens in a healthy man, in 17 (68%) of 25 specimens in prostatic cancer, in 10 (59%) of 17 specimens in lung cancer, and in 5 (30%) of 15 specimens in benign prostatic hyperplasia. Comparison of plasma levels of anti-plasminogen IgG by affinity chromatography showed 3-fold higher levels in patients with prostatic cancer vs. healthy men. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a autoantibodies  |2 nationallicence 
690 7 |a plasminogen  |2 nationallicence 
690 7 |a prostatic cancer  |2 nationallicence 
690 7 |a lung cancer  |2 nationallicence 
690 7 |a enzyme immunoassay  |2 nationallicence 
700 1 |a Goufman  |D E.  |u Research Institute of Physicochemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia  |4 aut 
700 1 |a Yakovlev  |D V.  |u Angiogen Company, Moscow, Russia  |4 aut 
700 1 |a Tikhonova  |D N.  |u Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Aisina  |D R.  |u Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia  |4 aut 
700 1 |a Yarygin  |D K.  |u V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Mukhametova  |D L.  |u Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia  |4 aut 
700 1 |a Gershkovich  |D K.  |u N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia  |4 aut 
700 1 |a Gulin  |D D.  |u N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 158/4(2015-02-01), 493-496  |x 0007-4888  |q 158:4<493  |1 2015  |2 158  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Goufman  |D E.  |u Research Institute of Physicochemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Yakovlev  |D V.  |u Angiogen Company, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Tikhonova  |D N.  |u Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Aisina  |D R.  |u Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Yarygin  |D K.  |u V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Mukhametova  |D L.  |u Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Gershkovich  |D K.  |u N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Gulin  |D D.  |u N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 158/4(2015-02-01), 493-496  |x 0007-4888  |q 158:4<493  |1 2015  |2 158  |o 10517