caa a22 4500 605538425 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2828-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2828-6 Pathways of Apoptosis Regulation in Hepatocytes Induced by First-Line Antitubercular Drugs [Elektronische Daten] [E. Bazhanova, D. Sukhanov, D. Teplyi] We studied pathways of apoptosis regulation during experimental hepatopathy caused by treatment with antitubercular drugs and involvement of some hepatoprotectors and immunomodulators in the regulation of hepatocyte apoptosis induced by antitubercular drugs. The intensity of apoptosis and expression of apoptosis-associated molecules were evaluated. It was shown that antitubercular drugs induce apoptosis in hepatocytes by triggering external signaling pathway and p53-dependent signaling pathway and simultaneously reducing the level of anti-apoptotic Bcl-2 protein. Runihol, remaxol, and cycloferon reduced degenerative effects in the liver, though the level of apoptosis remained high. Ademetionine in tablets and reamberin improved the microstructure of the liver by inhibiting both apoptotic pathways induced by the antitubercular drugs; in other words, they have distinct hepatoprotective and apoptosis-protective effects, which is especially important at the late stages of ontogeny. Springer Science+Business Media New York, 2015 hepatoprotector nationallicence apoptosis nationallicence apoptosis-protective activity nationallicence tuberculosis nationallicence liver damage nationallicence Bazhanova E. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia aut Sukhanov D. POLYSAN Company, St. Petersburg, Russia aut Teplyi D. Astrakhan State University, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 650-653 0007-4888 158:5<650 2015 158 10517 https://doi.org/10.1007/s10517-015-2828-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2828-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bazhanova E. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Sukhanov D. POLYSAN Company, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Teplyi D. Astrakhan State University, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 650-653 0007-4888 158:5<650 2015 158 10517