caa a22 4500 605538433 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2831-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2831-y Efficiency of Recombinant Thymosin β4 in Spontaneous Mouse Model of Chronic Dermatitis [Elektronische Daten] [E. Moiseeva, K. Beirakhova, S. Semushina, D. Aronov, D. Makarov, R. Esipov] The therapeutic efficiency of recombinant thymosin β4 (rTβ4) synthesized by us was studied in vivo on spontaneous CBRB mouse model that is adequate to human chronic dermatitis. Three applications of the drug during a week significantly alleviated symptoms of the disease in female mice, and in complex with subsequent antibacterial and antifungal therapy led to a pronounced and lasting (2 months) therapeutic effect. The results attest to a possibility of using rTβ4 in combination with the known treatment protocols for chronic inflammatory diseases of the skin. Springer Science+Business Media New York, 2015 thymosin β4 nationallicence immunotherapy nationallicence dermatitis nationallicence impetigo nationallicence mouse model nationallicence Moiseeva E. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Beirakhova K. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Semushina S. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Aronov D. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Makarov D. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Esipov R. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 670-672 0007-4888 158:5<670 2015 158 10517 https://doi.org/10.1007/s10517-015-2831-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2831-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moiseeva E. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Beirakhova K. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Semushina S. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Aronov D. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Makarov D. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Esipov R. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 670-672 0007-4888 158:5<670 2015 158 10517