Prenatal Effects of Peat Combustion Products and Afobazole Correction Thereof in the Rat Progeny

Verfasser / Beitragende:
[D. Gorbatova, E. Nemova, A. Solomina, A. Durnev, S. Seredenin]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 158/5(2015-03-01), 654-658
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2829-5  |2 doi 
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245 0 0 |a Prenatal Effects of Peat Combustion Products and Afobazole Correction Thereof in the Rat Progeny  |h [Elektronische Daten]  |c [D. Gorbatova, E. Nemova, A. Solomina, A. Durnev, S. Seredenin] 
520 3 |a Female outbred albino rats were daily subjected to forced inhalations of peat smoke (4 cores packed with a mixture of peat (70%) and wood pulp (30%); 0.46 g, pH ≥5.5) per se and in combination with oral afobazole (anxiolytic) on days 1-20 of pregnancy. Exposure to peat smoke inhibited body weight gain in pregnant rats, caused an increase of postimplantation deaths, reduction of fetal weights, and an increase in the number of hematomas and hemorrhages in fetuses. Afobazole in doses of 1 and 10 mg/kg reduced significantly the untoward effects of peat smoke on fetal development. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a peat smoke  |2 nationallicence 
690 7 |a rats  |2 nationallicence 
690 7 |a prenatal development  |2 nationallicence 
690 7 |a afobazole  |2 nationallicence 
700 1 |a Gorbatova  |D D.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Nemova  |D E.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Solomina  |D A.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Durnev  |D A.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
700 1 |a Seredenin  |D S.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Gorbatova  |D D.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Nemova  |D E.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Solomina  |D A.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Durnev  |D A.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Seredenin  |D S.  |u Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 158/5(2015-03-01), 654-658  |x 0007-4888  |q 158:5<654  |1 2015  |2 158  |o 10517