caa a22 4500 605538441 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2829-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2829-5 Prenatal Effects of Peat Combustion Products and Afobazole Correction Thereof in the Rat Progeny [Elektronische Daten] [D. Gorbatova, E. Nemova, A. Solomina, A. Durnev, S. Seredenin] Female outbred albino rats were daily subjected to forced inhalations of peat smoke (4 cores packed with a mixture of peat (70%) and wood pulp (30%); 0.46 g, pH ≥5.5) per se and in combination with oral afobazole (anxiolytic) on days 1-20 of pregnancy. Exposure to peat smoke inhibited body weight gain in pregnant rats, caused an increase of postimplantation deaths, reduction of fetal weights, and an increase in the number of hematomas and hemorrhages in fetuses. Afobazole in doses of 1 and 10 mg/kg reduced significantly the untoward effects of peat smoke on fetal development. Springer Science+Business Media New York, 2015 peat smoke nationallicence rats nationallicence prenatal development nationallicence afobazole nationallicence Gorbatova D. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Nemova E. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Solomina A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Durnev A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Seredenin S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 654-658 0007-4888 158:5<654 2015 158 10517 https://doi.org/10.1007/s10517-015-2829-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2829-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gorbatova D. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Nemova E. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Solomina A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Durnev A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Seredenin S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 654-658 0007-4888 158:5<654 2015 158 10517