caa a22 4500 60553845X CHVBK 20210128105200.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2822-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2822-z Role of NF-κB/IKK-Dependent Signaling in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine [Elektronische Daten] [G. Zyuz'kov, V. Zhdanov, E. Udut, L. Miroshnichenko, A. Chaikovskii, E. Simanina, M. Danilets, M. Minakova, V. Demkin, V. Udut, T. Tolstikova, E. Shults, V. Agafonov, A. Dygai] We studied the role of NF-κB/IKK-mediated signaling in the stimulation of growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Specific NF-κB inhibitor oridonin abolished activation of proliferation and differentiation of progenitor cells. Aurothiomalate, a selective blocker of IKK-2, also suppressed mitotic activity of fibroblast precursors, but had no effect on the rate of the differentiation. Springer Science+Business Media New York, 2015 intracellular signaling pathways nationallicence transcription factor NF-κB nationallicence alkaloids nationallicence progenitor cells nationallicence regenerative medicine nationallicence Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Zhdanov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Udut E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Simanina E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Danilets M. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Minakova M. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Demkin V. National Research Tomsk State University, Tomsk, Russia aut Udut V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Tolstikova T. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Shults E. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut Agafonov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Dygai A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 624-627 0007-4888 158:5<624 2015 158 10517 https://doi.org/10.1007/s10517-015-2822-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2822-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Zhdanov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Simanina E. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Danilets M. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Minakova M. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Demkin V. National Research Tomsk State University, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Tolstikova T. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Shults E. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Agafonov V. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Dygai A. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 624-627 0007-4888 158:5<624 2015 158 10517 SWISSBIB 51003022X