caa a22 4500 605538468 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2826-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2826-8 Transformation of Catalytic Characteristics of Cerebral Monoamine Oxidases in Experimental Posttraumatic Stress Disorders [Elektronische Daten] [L. Kolesnikova, A. Popova, R. Deev, A. Sinitskii, L. Krupitskaya] We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of experimental posttraumatic stress disorder. The detected shifts were comparable with the results of neuroethologic testing. The development of behavioral disorders presented by low exploratory activity and high anxiety was associated with transformation of catalytic characteristics of cerebral monoamine oxidases, associated with the development of oxidative stress with predominant intensification of metal-catalyzed protein oxidation. Springer Science+Business Media New York, 2015 monoamine oxidase nationallicence posttraumatic stress disorder nationallicence free radical oxidation nationallicence Kolesnikova L. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut Popova A. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut Deev R. South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Sinitskii A. South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Krupitskaya L. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 641-643 0007-4888 158:5<641 2015 158 10517 https://doi.org/10.1007/s10517-015-2826-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2826-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolesnikova L. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut NATIONALLICENCE 700 1- Popova A. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut NATIONALLICENCE 700 1- Deev R. South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Sinitskii A. South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Krupitskaya L. Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 641-643 0007-4888 158:5<641 2015 158 10517