caa a22 4500 605538484 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2832-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2832-x Polymorphisms of the Anti-Inflammatory IL-10 Gene Associated with Malignancy in Female Reproductive System [Elektronische Daten] [A. Tuguz, E. Anokhina, D. Muzhenya, K. Rudenko] Association of three polymorphisms (1082G/A, 819C/T, and 592C/A) of the promotor region of the anti-inflammatory IL-10 gene with malignancy of female reproductive organs was revealed by SNP (single nucleotide polymorphism) method in ethnic groups of Adygei Republic. Breast cancer, cervical cancer, and cancer of the uterine corpus are associated with allele 592A (р=0.042) in Circassians and with polymorphism 819T in Russians (р=0.046). Irrespective of the ethnicity, allele 819T was signifi cantly more often (р<0.05) detected in prevalent forms of breast cancer involving regional lymph nodes. 1082G polymorphism is associated with low-differentiated adenocarcinoma. In women of Adygei Republic, ATA/GCA gaplotypes are associated with high risk factors for breast cancer. Springer Science+Business Media New York, 2015 IL-10 nationallicence gene polymorphisms nationallicence malignancy nationallicence Tuguz A. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut Anokhina E. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut Muzhenya D. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut Rudenko K. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 673-675 0007-4888 158:5<673 2015 158 10517 https://doi.org/10.1007/s10517-015-2832-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2832-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tuguz A. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut NATIONALLICENCE 700 1- Anokhina E. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut NATIONALLICENCE 700 1- Muzhenya D. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut NATIONALLICENCE 700 1- Rudenko K. Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University, Adygei, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 673-675 0007-4888 158:5<673 2015 158 10517